The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy
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چکیده
منابع مشابه
Macrophage Cyclooxygenase-2 Protects Against Development of Diabetic Nephropathy
Diabetic nephropathy (DN) is characterized by increased macrophage infiltration, and proinflammatory M1 macrophages contribute to development of DN. Previous studies by us and others have reported that macrophage cyclooxygenase-2 (COX-2) plays a role in polarization and maintenance of a macrophage tissue-reparative M2 phenotype. We examined the effects of macrophage COX-2 on development of DN i...
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Diabetes mellitus (DM) is a health problem affecting millions of individuals worldwide. Diabetic nephropathy (DN), as a significant complication of DM, has become the most common cause of endstage renal failure. Oxidative stress constitutes the key and common events in the pathogenesis of DN and antioxidants may play a beneficial role in its prevention. This study was conducted to investigate t...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2013
ISSN: 0085-2538
DOI: 10.1038/ki.2013.11